LUNDBY LAB

Selected Publications

 

Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node

Cardiovascular Research (04 June 2024)

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Anniek Frederike Lubberding, Simon Veedfald, Jonathan Samuel Achter, Sarah Dalgas Nissen, Luca Soattin, Andrea Sorrentino, Estefania Torres Vega, Benedikt Linz, Caroline Harriet Eggert Eggertsen, John Mulvey, Signe Toräng, Sara Agnete Larsen, Anne Nissen, Lonnie Grove Petersen, Secil Erbil Bilir, Bo Hjorth Bentzen, Mette Marie Rosenkilde, Bolette Hartmann, Thomas Nikolaj Bang Lilleør, Saddiq Qazi, Christian Holdflod Møller, Jacob Tfelt-Hansen, Stefan Michael Sattler, Thomas Jespersen, Jens Juul Holst & Alicia Lundby

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Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction

Cardiovascular Research (25 April 2024)

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Konstantin Kahnert, Luca Soattin, Robert W Mills, Claire Wilson, Svetlana Maurya, Andrea Sorrentino, Sami Al-Othman, Roman Tikhomirov, Yordi J van de Vegte, Finn B Hansen, Jonathan Achter, Wei Hu, Min Zi, Matthew Smith, Pim van der Harst, Morten S Olesen, Kristine Boisen Olsen, Jytte Banner, Thomas H L Jensen, Henggui Zhang, Mark R Boyett, Alicia D’Souza & Alicia Lundby​

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Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram

Nature Cardiovascular Research (13 July 2023)

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Svetlana Maurya, Robert W. Mills, Konstantin Kahnert, David Y. Chiang, Giorgia Bertoli, Pia R. Lundegaard, Marta Perez-Hernandez Duran, Mingliang Zhang, Eli Rothenberg, Alfred L. George Jr., Calum A. MacRae, Mario Delmar & Alicia Lundby

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Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC

Circulation (12 August 2022)

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Marta Pérez-Hernández, Chantal JM van Opbergen, Navratan Bagwan, Christoffer Rasmus Vissing, Grecia M Marrón-Liñares, Mingliang Zhang, Estefania Torres Vega, Andrea Sorrentino, Lylia Drici, Karolina Sulek, Ruxu Zhai, Finn B Hansen, Alex Hørby Christensen, Søren Boesgaard, Finn Gustafsson, Kasper Rossing, Eric M Small, Michael J Davies, Eli Rothenberg, Priscila Sato, Marina Cerrone, Thomas Hartvig Lindkær Jensen, Klaus Qvortrup, Henning Bundgaard, Mario Delmar & Alicia Lundby

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Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2– Deficient Hearts

Circulation (10 May 2022)

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Chantal JM van Opbergen, Navratan Bagwan, Svetlana R Maurya, Joon-Chul Kim, Abigail N Smith, Daniel J Blackwell, Jeffrey N Johnston, Björn C Knollmann, Marina Cerrone, Alicia Lundby & Mario Delmar

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Quantitative proteome comparison of human hearts with those of model organisms

PLoS Biology (19 April 2021)

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Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W. Mills, Kirstine Calloe, Ulrike Leurs, Johan Z. Ye, Christian Stolte, Morten B. Thomsen, Bo H. Bentzen, Pia R. Lundegaard, Morten S. Olesen, Lars J. Jensen, Jesper V. Olsen & Alicia Lundby

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Oncotherapeutic Protein Kinase Inhibitors Associated With Pro-Arrhythmic Liability

JACC: CardioOncology (16 March 2021)

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Johan Z. Ye, Finn B. Hansen, Robert W. Mills & Alicia Lundby

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Quantitative Proteomics of Human Heart Samples Collected In Vivo Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation

Molecular & Cellular Proteomics (14 April 2020)

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Nora Linscheid, Pi Camilla Poulsen, Ida D. Pedersen, Emilie Gregers, Jesper H. Svendsen, Morten S. Olesen, Jesper V. Olsen, Mario Delmar & Alicia Lundby 

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Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase

Circulation (23 October 2020)

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Ling Xiao, Joe-Elie Salem, Sebastian Clauss, Alan Hanley, Aneesh Bapat, Maarten Hulsmans, Yoshiko Iwamoto, Gregory Wojtkiewicz, Murat Cetinbas, Maximilian J Schloss, Justin Tedeschi, Bénédicte Lebrun-Vignes, Alicia Lundby, Ruslan I Sadreyev, Javid Moslehi, Matthias Nahrendorf, Patrick T Ellinor & David J Milan

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Disruption of Ca 2+(i) Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice

Circulation (18 July 2020)

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Joon-Chul Kim, Marta Pérez-Hernández, Francisco J. Alvarado, Svetlana R. Maurya, Jerome Montnach, Yandong Yin, Mingliang Zhang, Xianming Lin, Carolina Vasquez, Adriana Heguy, Feng-Xia Liang, Sun-Hee Woo, Gregory E. Morley, Eli Rothenberg, Alicia Lundby, Hector H. Valdivia, Marina Cerrone & Mario Delmar 

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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

Cell (179, 2, p.543-560, 03 October 2019)

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Alicia Lundby, Giulia Franciosa, Kristina B. Emdal, Jan C. Refsgaard, Sebastian P. Gnosa, Dorte B. Bekker-Jensen, Anna Secher, Svetlana R. Maurya, Indranil Paul, Blanca, L. Mendez, Christian D. Kelstrup, Chiara Francavilla, Marie Kveiborg, Guillermo Montoya, Lars J. Jensen & Jesper V. Olsen

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Quantitative Proteomics and Single-nucleus Transcriptomics of the Sinus Node Elucidates the Foundation of Cardiac Pacemaking

Nature Communications (28 June 2019)

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Nora Linscheid, Sunil Jit R. J. Logantha, Pi Camilla Poulsen, Shanzhuo Zhang, Maren Schrölkamp, Kristoffer Lihme Egerod, Jonatan James Thompson, Ashraf Kitmitto, Gina Galli, Martin J. Humphries, Henggui Zhang, Tune H. Pers, Jesper Velgaard Olsen, Mark Boyett & Alicia Lundby

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Annotation of Loci from Genome-wide Association Studies using Tissue-specific Quantitative Interaction Proteomics

​Nature Methods (11, 8, p.868-874, 22 June 2014)

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Lundby, A., Rossin, E. J., Steffensen, A. B., Acha, M. R., Newton-Cheh, C., Pfeufer, A., Lynch, S. N., Olesen, S-P., Brunak, S., Ellinor, P. T., Jukema, J. W., Trompet, S., Ford, I., Macfarlane, P. W., Krijthe, B. P., Hofman, A., Uitterlinden, A. G., Stricker, B. H., Nathoe, H. M., Spiering, W., Daly, M. J., Asselbergs, F. W., van der Harst, P., Milan, D. J., de Bakker, P. I. W., Hansen, K. L., Olsen, J. V. & The QT Interval International GWAS Consortium (QT-IGC)

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Genetic Association Study of QT Interval Highlights Role for Calcium Signaling Pathways in Myocardial Repolarization

Nature genetics (46, 8, p.826-838, 22 June 2014)

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Arking, D. E., Pulit, S. L., Crotti, L., van der Harst, P., Munroe, P. B., Koopmann, T. T., Sotoodehnia, N., Rossin, E. J., Morley, M., Wang, X., Johnson, A. D., Lundby, A., Gudbjartsson, D. F., Noseworthy, P. A., Eijgelsheim, M., Bradford, Y., Tarasov, K. V., Dörr, M., Müller-Nurasyid, M., Lahtinen, A. M., Nolte, I. M., Smith, A. V., Bis, J. C., Isaacs, A., Newhouse, S. J., Evans, D. S., Post, W. S., Waggott, D., Lyytikäinen, L-P., Hicks, A. A., Eisele, L., Ellinghaus, D., Hayward, C., Navarro, P., Ulivi, S., Tanaka, T., Tester, D. J., Chatel, S., Gustafsson, S., Kumari, M., Morris, R. W., Naluai, A. T., Padmanabhan, S., Kluttig, A., Strohmer, B., Panayiotou, A. G., Torres, M., Knoflach, M., Olsen, J. V., Hansen, K. L. & CARe Consortium

 

In Vivo Phosphoproteomics Analysis Reveals the Cardiac Targets of β-Adrenergic Receptor Signaling

Science Signaling (6, 278, 4 June 2013)

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Lundby, A., Andersen, M. N., Steffensen, A. B., Horn, H., Kelstrup, C. D., Francavilla, C., Jensen, L. J., Schmitt, N., Thomsen, M. B. & Olsen, J. V.

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Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns

Cell Reports (2, 2, p.419-431, 30 August 2012)

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Lundby, A., Hansen, K. L., Weinert, B. T., Breinholt Bekker-Jensen, D., Secher, A., Skovgaard, T., Kelstrup, C., Dmytriyev, A., Choudhary, C. R., Lundby, C. & Olsen, J. V.

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Quantitative Maps of Protein Phosphorylation Sites Across 14 Different Rat Organs and Tissues

Nature Communications (3, 876, 6 June 2012)

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Lundby, A., Secher, A., Lage, K., Nordsborg, N. B., Dmytriyev, A., Lundby, C. & Olsen, J. V.

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